Clinical Need

Volume Status

Knowing volume status is key in critical care. The American College of Cardiology and American Heart Association recommend assessing volume status in all heart failure patients. Even small 10% increases in volume are directly linked to worse outcomes and longer hospital stays. A third of all ICU patients has an episode of volume resuscitation, and a quarter of all ICU patients suffer from acute kidney injury (AKI).

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mGFR vs. eGFR

In kidney disease, Glomerular Filtration Rate (GFR) is the primary indicator of injury, disease progression, and recovery. Currently, Serum Creatinine (SCr) is the most common clinical assay for estimating renal function (eGFR). This is a poor surrogate for true GFR as it is a trailing indicator by approximately 24-48 hours. Patients lose approximately 50% of their kidney function by the time the serum creatinine measures above normal. It is slow to reflect kidney impairment and recovery and is impacted by non-renal factors of age, diet, muscle mass, and hemodynamics.

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